Vitamin D: its role and uses in immunology.

TitleVitamin D: its role and uses in immunology.
Publication TypeJournal Article
Year of Publication2001
AuthorsDeluca HF, Cantorna MT
JournalThe FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume15
Issue14
Pagination2579-85
Date Published2001 Dec
ISSN1530-6860
KeywordsAnimals, Autoimmune Diseases, Diabetes Mellitus, Type 1, Humans, Immune System, Receptors, Calcitriol, Vitamin D, Vitamin D Deficiency
Abstract

In recent years there has been an effort to understand possible noncalcemic roles of vitamin D, including its role in the immune system and, in particular, on T cell-medicated immunity. Vitamin D receptor is found in significant concentrations in the T lymphocyte and macrophage populations. However, its highest concentration is in the immature immune cells of the thymus and the mature CD-8 T lymphocytes. The significant role of vitamin D compounds as selective immunosuppressants is illustrated by their ability to either prevent or markedly suppress animal models of autoimmune disease. Results show that 1,25-dihydroxyvitamin D3 can either prevent or markedly suppress experimental autoimmune encephalomyelitis, rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, and inflammatory bowel disease. In almost every case, the action of the vitamin D hormone requires that the animals be maintained on a normal or high calcium diet. Possible mechanisms of suppression of these autoimmune disorders by the vitamin D hormone have been presented. The vitamin D hormone stimulates transforming growth factor TGFbeta-1 and interleukin 4 (IL-4) production, which in turn may suppress inflammatory T cell activity. In support of this, the vitamin D hormone is unable to suppress a murine model of the human disease multiple sclerosis in IL-4-deficient mice. The results suggest an important role for vitamin D in autoimmune disorders and provide a fertile and interesting area of research that may yield important new therapies.

Alternate JournalFASEB J.
PubMed ID11726533
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