Risks and benefits of hormone replacement therapy: the evidence speaks.

TitleRisks and benefits of hormone replacement therapy: the evidence speaks.
Publication TypeJournal Article
Year of Publication2003
AuthorsHumphries KH, Gill S
JournalCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Date Published2003 Apr 15
KeywordsCanada, Cardiovascular Diseases, Estrogen Replacement Therapy, Estrogens, Evidence-Based Medicine, Female, Humans, Middle Aged, Neoplasms, Risk Factors, Women's Health

Until recently, observational studies suggested a decreased risk of cardiovascular disease, osteoporotic fractures, cognitive decline and colon cancer with the use of hormone replacement therapy (HRT). Recent randomized controlled trials have failed to show a protective effect of HRT in reducing the risk of coronary artery disease and instead have revealed an increased risk of heart disease, stroke, invasive breast cancer and venous thromboembolism, but a decreased risk of colorectal cancer and osteoporotic fractures. In this article we review the current evidence of the risks and benefits of HRT.

Alternate JournalCMAJ
PubMed ID12695385
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