Risk factors in calcium stone disease of the urinary tract.

TitleRisk factors in calcium stone disease of the urinary tract.
Publication TypeJournal Article
Year of Publication1978
AuthorsRobertson WG, Peacock M, Heyburn PJ, Marshall DH, Clark PB
JournalBritish journal of urology
Date Published1978 Dec
KeywordsAdult, Calcium Oxalate, Calcium Phosphates, Child, Female, Glycosaminoglycans, Humans, Hydrogen-Ion Concentration, Male, Methods, Risk, Uric Acid, Urinary Calculi

The concept that calcium stone formation may be explained on the basis of a number of risk factors is developed. The main risk factors involved are shown to be calcium, oxalate, pH, acid mucopolysaccharides and uric acid. A method is described for calculating and combining the individual risk factors into a measure of the "relative probability" of forming stones (PSF). PSF values are generally lower in normal subjects than in stone-formers. Amongst the normals, PSF values are lower in children and women than in men. Recurrent stone-formers have the highest PSF values and these correlate well with the severity of the diseases as defined by the stone episode rate of the patient. Single stone-formers have PSF values intermediate between those of normal men and those of recurrent stone-formers.

Alternate JournalBr J Urol
PubMed ID37975
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