A review of new concepts in renal stone research.

TitleA review of new concepts in renal stone research.
Publication TypeJournal Article
Year of Publication1993
AuthorsCao LC, Boevé ER, de Bruijn WC, Robertson WG, Schröder FH
JournalScanning microscopy
Pagination1049-64; discussion 1064-5
Date Published1993 Sep
KeywordsBiological Transport, Active, Crystallization, Free Radicals, Humans, Kidney Calculi, Kidney Tubules, Oxalates

Clinical and basic research in the field of urolithiasis has developed rapidly in recent years. Progress in extracorporeal shock wave lithotripsy (ESWL) and percutaneous nephrolithotomy (PNL) has brought about a revolution in the surgical treatment of urolithiasis and research at the cellular and molecular level is now expanding. In spite of these advances, however, clinical treatment of urolithiasis remains far from satisfactory. Stone recurrence in many patients cannot be predicted and is beyond control of urologists mainly because the mechanisms of stone formation are still not fully understood. It is necessary to study the process of stone-formation more intensely at the cellular and molecular level, and to strengthen the links between basic and clinical research in the field. In this review, the processes involved in the formation of stones are compared with those involved in normal bio-mineralization and a model of urolithiasis is put forward based on modern systems science. Attention is concentrated on: (a) Directions of research based on physico-chemical theories of stone formation; (b) The role of renal tubular defects in urolithiasis; (c) The role of free radical reactions in stone formation; and (d) Macromolecular abnormalities and their correction.

Alternate JournalScanning Microsc.
PubMed ID8146606
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