Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.

TitleReversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.
Publication TypeJournal Article
Year of Publication1999
AuthorsJoseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, Bickford PC
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Volume19
Issue18
Pagination8114-21
Date Published1999 Sep 15
ISSN1529-2401
KeywordsAging, Animals, Calcium, Cognition, Corpus Striatum, Dietary Supplements, Dopamine, Fruit, Glutathione, Maze Learning, Motor Activity, Neurons, Plant Extracts, Potassium, Psychomotor Performance, Rats, Rats, Inbred F344, Signal Transduction, Spinacia oleracea, Synaptosomes
Abstract

Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress that may be ameliorated by antioxidants. Our previous study had shown that rats given dietary supplements of fruit and vegetable extracts with high antioxidant activity for 8 months beginning at 6 months of age retarded age-related declines in neuronal and cognitive function. The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance. These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.

Alternate JournalJ. Neurosci.
PubMed ID10479711
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