Resonance Raman spectroscopic evaluation of skin carotenoids as a biomarker of carotenoid status for human studies.

TitleResonance Raman spectroscopic evaluation of skin carotenoids as a biomarker of carotenoid status for human studies.
Publication TypeJournal Article
Year of Publication2013
AuthorsMayne ST, Cartmel B, Scarmo S, Jahns L, Ermakov IV, Gellermann W
JournalArchives of biochemistry and biophysics
Volume539
Issue2
Pagination163-70
Date Published2013 Nov 15
ISSN1096-0384
KeywordsAging, Biological Markers, Carotenoids, Diet Therapy, Feasibility Studies, Humans, Scattering, Radiation, Skin Diseases, Spectrum Analysis, Raman
Abstract

Resonance Raman spectroscopy (RRS) is a non-invasive method that has been developed to assess carotenoid status in human tissues including human skin in vivo. Skin carotenoid status has been suggested as a promising biomarker for human studies. This manuscript describes research done relevant to the development of this biomarker, including its reproducibility, validity, feasibility for use in field settings, and factors that affect the biomarker such as diet, smoking, and adiposity. Recent studies have evaluated the response of the biomarker to controlled carotenoid interventions, both supplement-based and dietary [e.g., provision of a high-carotenoid fruit and vegetable (F/V)-enriched diet], demonstrating consistent response to intervention. The totality of evidence supports the use of skin carotenoid status as an objective biomarker of F/V intake, although in the cross-sectional setting, diet explains only some of the variation in this biomarker. However, this limitation is also a strength in that skin carotenoids may effectively serve as an integrated biomarker of health, with higher status reflecting greater F/V intake, lack of smoking, and lack of adiposity. Thus, this biomarker holds promise as both a health biomarker and an objective indicator of F/V intake, supporting its further development and utilization for medical and public health purposes.

DOI10.1016/j.abb.2013.06.007
Alternate JournalArch. Biochem. Biophys.
PubMed ID23823930
Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon
Get email updates
Recipes. upcoming classes.