Nitrite promotes lymphoma incidence in rats.

Notes: 

Nitrite promotes lymphoma incidence in rats.

TitleNitrite promotes lymphoma incidence in rats.
Publication TypeJournal Article
Year of Publication1979
AuthorsNewberne PM
JournalScience (New York, N.Y.)
Volume204
Issue4397
Pagination1079-81
Date Published1979 Jun 8
ISSN0036-8075
KeywordsAnimals, Dose-Response Relationship, Drug, Lymphocytes, Lymphoma, Neoplasms, Experimental, Nitrites, Rats
Abstract

Rats were exposed to sodium nitrite in food or water at concentrations of 0, 250, 1000, and 2000 parts per million. Lymphoma was increased in all groups fed nitrite; the overall combined incidence was 5.4 percent in 573 control rats and 10.2 percent in 1383 treated rats. The mechanism of cancer induction did not appear to be through the formation of nitrosamines but through a more direct effect of nitrite on the lymphocyte.

Alternate JournalScience
PubMed ID451551
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