Link between heart disease, cholesterol, and Alzheimer's disease: a review.

TitleLink between heart disease, cholesterol, and Alzheimer's disease: a review.
Publication TypeJournal Article
Year of Publication2000
AuthorsSparks DL, Martin TA, Gross DR, Hunsaker JC
JournalMicroscopy research and technique
Date Published2000 Aug 15
KeywordsAlzheimer Disease, Amyloid beta-Peptides, Animals, Cholesterol, Disease Models, Animal, Heart Diseases, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypertension, Plaque, Amyloid

Increased prevalence of Alzheimer's disease-like beta-amyloid deposits in the neuropil and within neurons occurs in the brains of non-demented individuals with heart disease. Heart disease is a prevalent finding in Alzheimer's disease, and may be a forerunner to the dementing disorder. In the cholesterol-fed rabbit model of human coronary heart disease there is production and accumulation of beta-amyloid in the brain. This accumulation of beta-amyloid can be reversed by removing cholesterol from the rabbits' diet. In culture cells, a cholesterol challenge has been shown to increase production of beta-amyloid, and dramatic reductions of cholesterol produced by HMG Co-A reductase inhibitors decrease production of beta-amyloid. Increased beta-amyloid production is also produced by dietary cholesterol in a number of transgenic mouse models of Alzheimer's disease. Administration of HMG Co-A reductase inhibitors may block beta-amyloid production caused by dietary cholesterol in rabbits. Clinical trials testing the benefit of HMG Co-A reductase inhibitors in the treatment of Alzheimer's disease are underway.

Alternate JournalMicrosc. Res. Tech.
PubMed ID10936882
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