Lifetime menstrual activity--indicator of breast cancer risk.

Notes: 

Lifetime menstrual activity is an indicator of breast cancer risk.

TitleLifetime menstrual activity--indicator of breast cancer risk.
Publication TypeJournal Article
Year of Publication1993
AuthorsRautalahti M, Albanes D, Virtamo J, Palmgren J, Haukka J, Heinonen OP
JournalEuropean journal of epidemiology
Volume9
Issue1
Pagination17-25
Date Published1993 Jan
ISSN0393-2990
KeywordsAdult, Age Factors, Aged, Breast Neoplasms, Case-Control Studies, Contraceptives, Oral, Estrogen Replacement Therapy, Female, Finland, Humans, Logistic Models, Menopause, Menstruation, Middle Aged, Questionnaires, Risk Factors, Smoking, Time Factors
Abstract

A case-control study of 67 cases of breast cancer and 157 controls was conducted to investigate the role of different behavioral, reproductive, and hormonal factors and to develop a unifying indicator of breast cancer risk. The results confirm previous reports of the influence of smoking on the risk of breast cancer. Age at menarche was found to be a risk factor among the premenopausal women. Late age at menopause was suggestive of an increase in risk. Long use of oral contraceptive or estrogen supplementation were risk-enhancing both pre- and postmenopausally. Lifetime duration of menstrual activity (LMA) combines age at menarche and menopause, parity, and lactation into a biologically plausible model. Our findings concerning LMA support its role as a determinant of breast cancer.

Alternate JournalEur. J. Epidemiol.
PubMed ID8472797
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