Inhibition of aflatoxin-initiated preneoplastic liver lesions by low dietary protein.


Measure foci development and number: "Foci development was almost entirely dependent on how much protein was consumed, regardless of how much aflatoxin was consumed."

TitleInhibition of aflatoxin-initiated preneoplastic liver lesions by low dietary protein.
Publication TypeJournal Article
Year of Publication1982
AuthorsAppleton BS, Campbell TC
JournalNutrition and cancer
Date Published1982
KeywordsAflatoxin B1, Aflatoxins, Animals, Caseins, gamma-Glutamyltransferase, Liver, Liver Neoplasms, Experimental, Male, Precancerous Conditions, Rats

The development of aflatoxin B1-induced hepatic preneoplastic lesions was significantly modified by varying the level of dietary casein fed to animals during the post-dosing period. Using gamma-glutamyl transferase staining to identify areas of cellular alteration, we observed that animals fed a 5% casein diet showed a 75% reduction in lesion development as compared to animals fed a 20% casein diet. Increasing the level of dietary casein from 20% to 40% produced no further increase in response. The results of the study, showing an inhibition in the preneoplastic development by a reduction dietary casein after aflatoxin dosing, suggest that low dietary casein inhibits the promotional phase of the ultimate neoplastic response.

Alternate JournalNutr Cancer
PubMed ID6128727
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