High-fat, low-carbohydrate diet and the etiology of non-insulin-dependent diabetes mellitus: the San Luis Valley Diabetes Study.


San Luis Valley Diabetes Study: fat intake associated with increased rate of Type 2 diabetes

TitleHigh-fat, low-carbohydrate diet and the etiology of non-insulin-dependent diabetes mellitus: the San Luis Valley Diabetes Study.
Publication TypeJournal Article
Year of Publication1991
AuthorsMarshall JA, Hamman RF, Baxter J
JournalAmerican journal of epidemiology
Date Published1991 Sep 15
KeywordsAdult, Aged, Confidence Intervals, Cross-Sectional Studies, Diabetes Mellitus, Type 2, diet, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Female, Glucose Tolerance Test, Hispanic Americans, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk

Diet has long been believed to be an important risk factor for non-insulin-dependent diabetes. Animal studies generally support a relation between high-fat diets and development of insulin resistance. However, conclusive epidemiologic evidence is lacking. To further investigate the role of dietary fat and carbohydrate as potential risk factors for the onset of non-insulin-dependent diabetes mellitus, current diet was assessed among a geographically based group of 1,317 subjects without a prior diagnosis of diabetes who were seen in the period from 1984 to 1988 in two countries in southern Colorado. In this study, 24-hour diet recalls were reported prior to an oral glucose tolerance test. Persons with previously undiagnosed diabetes (n = 70) and impaired glucose tolerance (n = 171) were each compared with confirmed normal controls (n = 1,076). The adjusted odds ratios relating a 40-g/day increase in fat intake to non-insulin-dependent diabetes mellitus and impaired glucose tolerance were 1.51 (95% confidence interval 0.85-2.67) and 1.62 (95% confidence interval 1.09-2.41), respectively. Restricting cases to diabetic persons with fasting glucose greater than 140 mg/dl and persons with impaired glucose tolerance confirmed on follow-up, the odds ratios increased to 3.03 (95% confidence interval 1.07-8.62) and 2.67 (95% confidence interval 1.33-5.36), respectively. The findings support the hypothesis that high-fat, low-carbohydrate diets are associated with the onset of non-insulin-dependent diabetes mellitus in humans.

Alternate JournalAm. J. Epidemiol.
PubMed ID1951264
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