Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts.

TitleFlaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts.
Publication TypeJournal Article
Year of Publication2002
AuthorsDabrosin C, Chen J, Wang L, Thompson LU
JournalCancer letters
Volume185
Issue1
Pagination31-7
Date Published2002 Nov 8
ISSN0304-3835
KeywordsAnimals, Body Weight, Down-Regulation, Endothelial Growth Factors, Estrogens, Non-Steroidal, Extracellular Space, Female, Flax, Humans, Intercellular Signaling Peptides and Proteins, Isoflavones, Lung Neoplasms, Lymphatic Metastasis, Lymphokines, Mammary Neoplasms, Experimental, Mice, Mice, Nude, Neoplasm Transplantation, Phytoestrogens, Plant Preparations, Seeds, Transplantation, Heterologous, Tumor Cells, Cultured, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors
Abstract

Angiogenesis is important in tumor growth, progression and metastatic dissemination. Vascular endothelial growth factor (VEGF) is one key factor in promotion of breast cancer angiogenesis. VEGFs are bioactive in the extracellular space where they become available to the endothelial cells. Phytoestrogens such as lignans have been shown to alter breast cancer incidence and be cancer-protective in rats. We show that supplementation of 10% flaxseed, the richest source of mammalian lignans, to nude mice with established human breast tumors reduced tumor growth and metastasis. Moreover, flaxseed decreased extracellular levels of VEGF, which may be one mechanistic explanation to the decreased tumor growth and metastasis.

Alternate JournalCancer Lett.
PubMed ID12142076
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