Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population.

TitleEvidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population.
Publication TypeJournal Article
Year of Publication1992
AuthorsBodansky HJ, Staines A, Stephenson C, Haigh D, Cartwright R
JournalBMJ (Clinical research ed.)
Volume304
Issue6833
Pagination1020-2
Date Published1992 Apr 18
ISSN0959-8138
KeywordsAdolescent, Asia, Child, Child, Preschool, Diabetes Mellitus, Type 1, England, Environment, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Sex Factors
Abstract

OBJECTIVE: To examine whether children of families moving from an area of low incidence of childhood diabetes to one which is higher show a corresponding rise in disease incidence.

DESIGN: Disease incidence study over 12 years.

SETTING: Bradford District Metropolitan Council area.

SUBJECTS: All subjects aged 0-16 years resident within the study area.

MAIN OUTCOME MEASURES: The incidences of childhood diabetes in Asian and non-Asian families.

RESULTS: The incidence of diabetes in Asian children increased from 3.1/100,000 per year in 1978-81 to 11.7/100,000 per year in 1988-90 (chi 2 for trend = 4.95, df = 1, p = 0.026) whereas that for other children remained constant at 10.5/100,000 per year. Over the entire study period rates were lower in Asian females (4.9/100,000 per year) than in Asian males (8.8/100,000 per year) whereas the reverse was true for other children (males 9.2/100,000 per year; females 12.0/100,000 per year) (test for common odds ratio: chi 2 = 3.81, df = 1, p = 0.052).

CONCLUSIONS: Offspring of this transmigratory population had a rising incidence of childhood diabetes which was approaching that of the indigenous population. The data provide strong evidence for an environmental effect in the aetiology of insulin dependent diabetes.

Alternate JournalBMJ
PubMed ID1586783
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