Encephalopathy and stroke after coronary artery bypass grafting: incidence, consequences, and prediction.


Prospective study. CABG patients at higher risk for stroke and encephalopathy can be identified before surgery. 1 in 10 will have a stroke or encephalopathy (delirium or coma).

TitleEncephalopathy and stroke after coronary artery bypass grafting: incidence, consequences, and prediction.
Publication TypeJournal Article
Year of Publication2002
AuthorsMcKhann GM, Grega MA, Borowicz LM, Bechamps M, Selnes OA, Baumgartner WA, Royall RM
JournalArchives of neurology
Date Published2002 Sep
KeywordsAged, Anesthesia, Brain Diseases, Cardiopulmonary Bypass, Coronary Artery Bypass, Female, Humans, Length of Stay, Logistic Models, Male, Middle Aged, Perfusion, Postoperative Complications, Prospective Studies, Risk Factors, Stroke

BACKGROUND: In contrast to perioperative stroke, much less attention has been paid to those with evidence of diffuse brain encephalopathy, presenting as delirium, confusion, coma, and seizures in the immediate postoperative period.

OBJECTIVE: To determine the incidence, consequences, and predictive factors for encephalopathy and stroke following coronary artery bypass grafting.

METHODS: In a prospective evaluation of 2711 patients operated on between January 1, 1997, and December 31, 2000, preoperative risk factors were obtained before surgery and postoperative outcomes, encephalopathy and stroke, were determined on a daily basis. All strokes were confirmed by neurologic consultation and, in most instances, by imaging. Logistic regression analyses were performed to determine risk factors for these outcomes.

RESULTS: The incidence of encephalopathy was 6.9% and of stroke, 2.7%. For patients without either of these outcomes, the average length of stay in the hospital was 6.6 days and the mortality was 1.4%. In contrast, patients with encephalopathy had a length of stay of 15.2 days and a mortality of 7.5%, and those with stroke, a length of stay of 17.5 days and a mortality of 22.0%. Predictive models were developed for encephalopathy involving 5 preoperative factors (age, past stroke, carotid bruit, hypertension, and diabetes) and 1 perioperative factor (time on cardiopulmonary bypass). The model for stroke involved only 3 preoperative risk factors (past stroke, hypertension, and diabetes).

CONCLUSIONS: Encephalopathy or stroke is associated with significant increases in length of stay and mortality after coronary artery bypass grafting. Patients at higher risk for these outcomes can be identified before surgery.

Alternate JournalArch. Neurol.
PubMed ID12223028
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