Effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet on levels of serum lipids and estradiol.

TitleEffects of a high-complex-carbohydrate, low-fat, low-cholesterol diet on levels of serum lipids and estradiol.
Publication TypeJournal Article
Year of Publication1985
AuthorsRosenthal MB, Barnard RJ, Rose DP, Inkeles S, Hall J, Pritikin N
JournalThe American journal of medicine
Volume78
Issue1
Pagination23-7
Date Published1985 Jan
ISSN0002-9343
KeywordsBlood Glucose, Body Weight, Cholesterol, Dietary, Cholesterol, HDL, Dietary Carbohydrates, Dietary Fats, Estradiol, Humans, Male, Middle Aged, Myocardial Infarction, Physical Exertion, Risk, Testosterone
Abstract

Recent studies have implicated elevated levels of serum estradiol in males as the major predisposing factor for myocardial infarction, with serum cholesterol playing a secondary role. The purpose of the present study was to investigate the effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet and daily exercise on levels of serum estradiol, testosterone, and lipids in males. Twenty-one males participating in the Pritikin Longevity Center 26-day residential program volunteered for the study. During the program, serum estradiol levels were significantly reduced from 47.2 +/- 4.6 to 23.8 +/- 2.5 pg/ml (mean +/- SE) whereas serum testosterone levels were unchanged (5.1 +/- 0.3 versus 5.1 +/- 0.2 ng/ml). Total serum cholesterol levels were reduced from 229 +/- 9 to 181 +/- 7 mg/dl whereas triglyceride levels were reduced from 301 +/- 66 to 151 +/- 13 mg/dl. High-density lipoprotein-cholesterol levels fell from 41 +/- 3 to 35 +/- 1 mg/dl whereas the ratio of total cholesterol to high-density lipoprotein-cholesterol was unchanged (5.5 +/- 0.4 versus 5.1 +/- 0.3).

Alternate JournalAm. J. Med.
PubMed ID3966484
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