Effect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat pancreas.

Notes: 

Animal (not plant) protein promotes cancer

TitleEffect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat pancreas.
Publication TypeJournal Article
Year of Publication1985
AuthorsO'Connor TP, Roebuck BD, Peterson F, Campbell TC
JournalJournal of the National Cancer Institute
Volume75
Issue5
Pagination959-62
Date Published1985 Nov
ISSN0027-8874
KeywordsAnimals, Azaserine, Caseins, Corn Oil, Dietary Proteins, Female, Fish Oils, Fish Products, Male, Oils, Pancreatic Neoplasms, Precancerous Conditions, Rats, Rats, Inbred Strains
Abstract

The effect of dietary intake of fish (menhaden) oil and fish (cod) protein on the development of pancreatic preneoplastic lesions was examined in male Wistar rats. Fourteen-day-old animals were given a single ip injection of 30 mg L-azaserine/kg body weight [CAS: 115-02-6; diazoacetate serine (ester)]. At 21 days of age they were weaned and maintained on dietary treatment for 4 months. Fish protein did not appear to produce a significantly different preneoplastic response when compared to casein as a protein source. However, a 20% menhaden oil diet, rich in omega 3 fatty acids, produced a significant decrease in the development of both the size and number of preneoplastic lesions when compared to a 20% corn oil diet rich in omega 6 fatty acids. This study provides evidence that fish oils, rich in omega 3 fatty acids, may have potential as inhibitory agents in cancer development.

Alternate JournalJ. Natl. Cancer Inst.
PubMed ID3863992
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