Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys.

Notes: 

DHA can reduce the severity or delay the development of levodopa-induced dyskinesias (LIDs) in a nonhuman primate (monkey) model of Parkinson's disease.

TitleDocosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys.
Publication TypeJournal Article
Year of Publication2006
AuthorsSamadi P, Grégoire L, Rouillard C, Bédard PJ, Di Paolo T, Lévesque D
JournalAnnals of neurology
Volume59
Issue2
Pagination282-8
Date Published2006 Feb
ISSN0364-5134
KeywordsAnalysis of Variance, Animals, Antiparkinson Agents, Behavior, Animal, Disease Models, Animal, Docosahexaenoic Acids, Dose-Response Relationship, Drug, Drug Interactions, Dyskinesias, Female, Levodopa, Macaca fascicularis, Motor Activity, MPTP Poisoning, Ovariectomy, Severity of Illness Index, Time Factors
Abstract

OBJECTIVE: The objective of the present study was to investigate the effect of docosahexaenoic acid (DHA), a polyunsaturated fatty acid (omega-3), on levodopa-induced dyskinesias (LIDs) in parkinsonian 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys.

METHODS: We explored the effect of DHA in two paradigms. First, a group of MPTP monkeys was primed with levodopa for several months before introducing DHA. A second group of MPTP monkeys (de novo) was exposed to DHA before levodopa therapy.

RESULTS: DHA administration reduced LIDs in both paradigms without alteration of the anti-parkinsonian effect of levodopa indicating that DHA can reduce the severity or delay the development of LIDs in a nonhuman primate model of Parkinson's disease.

INTERPRETATION: These results suggest that DHA can reduce the severity or delay the development of LIDs in a nonhuman primate model of Parkinson's disease. DHA may represent a new approach to improve the quality of life of Parkinson's disease patients.

Alternate JournalAnn. Neurol.
PubMed ID16437566
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