Dietary intervention during the postdosing phase of L-azaserine-induced preneoplastic lesions.

Notes: 

(Paper was featured on the cover.)

TitleDietary intervention during the postdosing phase of L-azaserine-induced preneoplastic lesions.
Publication TypeJournal Article
Year of Publication1985
AuthorsO'Connor TP, Roebuck BD, Campbell TC
JournalJournal of the National Cancer Institute
Volume75
Issue5
Pagination955-7
Date Published1985 Nov
ISSN0027-8874
KeywordsAnimals, Azaserine, Corn Oil, Dietary Fats, Female, Male, Oils, Pancreatic Neoplasms, Precancerous Conditions, Rats, Rats, Inbred Strains
Abstract

The effects of intervention by diets with high or low levels of dietary fat on the development of preneoplastic pancreatic lesions were examined. Wistar rats were treated ip at 14 days of age with a 30-mg/kg dose of L-azaserine [CAS: 115-02-6; diazoacetate serine (ester)] and weaned onto the test diets. Animals fed 5% corn oil had fewer preneoplastic lesions compared to animals fed 20% corn oil throughout the 4-month posttreatment period. The strong response observed in rats fed 20% corn oil could be markedly reduced by intervention with a 5% corn oil diet halfway through the posttreatment period. Similarly, the low response in animals fed 5% corn oil could be markedly elevated by intervention with a high-fat diet. These results provide evidence for the hypothesis that tumor development may be modified by dietary means.

Alternate JournalJ. Natl. Cancer Inst.
PubMed ID3863991
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