Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk.

Notes: 

Cruciferous vegetable (Chinese cabbage, bok choy, turnips) intake consistent with high isothiocyanate exposure may reduce breast cancer risk. Cruciferous vegetable intake also may ameliorate the effects of the GSTP1 genotype (which predisposes people to breast cancer). Subjects reporting greater turnip and Chinese cabbage intakes had a significantly lower postmenopausal breast cancer risk (half as much cancer). Women with the GSTP1 Val/Val genotype and low cruciferous vegetable intake had a breast cancer risk 1.74-fold that of women with the Ile/Ile or Ile/Val genotype. This effect of low cruciferous vegetable intake and the Val/Val genotype was seen predominantly among premenopausal women.

Half the cancer with higher intake.

TitleCruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk.
Publication TypeJournal Article
Year of Publication2008
AuthorsLee S-A, Fowke JH, Lu W, Ye C, Zheng Y, Cai Q, Gu K, Gao Y-T, Shu X-ou, Zheng W
JournalThe American journal of clinical nutrition
Volume87
Issue3
Pagination753-60
Date Published2008 Mar
ISSN1938-3207
KeywordsAdult, Brassicaceae, Breast Neoplasms, Case-Control Studies, Confidence Intervals, Female, Genotype, Glutathione S-Transferase pi, Glutathione Transferase, Humans, Isothiocyanates, Logistic Models, Middle Aged, Multivariate Analysis, Nutrigenomics, Odds Ratio, Polymorphism, Genetic, Postmenopause, Premenopause, Risk Factors, Vegetables
Abstract

BACKGROUND: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs).

OBJECTIVE: We investigated the independent and combined effects of cruciferous vegetable intake and the GSTP1 Ile(105)Val genetic polymorphism on breast cancer risk.

DESIGN: Analyses included 3035 cases and 3037 population controls who were participating in the Shanghai Breast Cancer Study and for whom diet and genetic data were complete (87% of cases and 85% of controls).

RESULTS: With the use of multivariate logistic regression, the GSTP1 Val/Val genotype was significantly associated with greater breast cancer risk (OR = 1.50; 95% CI: 1.12, 1.99). The association was significantly greater in premenopausal women (OR = 1.69; 95% CI: 1.17, 2.43) than in postmenopausal women (OR = 1.20; 95% CI: 0.74, 1.92). Total cruciferous vegetable intake was not significantly associated with breast cancer risk, although subjects reporting greater turnip (P for trend < 0.001) and Chinese cabbage (P for trend = 0.049) intakes had a significantly lower postmenopausal breast cancer risk. Women with the GSTP1 Val/Val genotype and low cruciferous vegetable intake had a breast cancer risk 1.74-fold (95% CI: 1.13, 2.67) that of women with the Ile/Ile or Ile/Val genotype. This effect of low cruciferous vegetable intake and the Val/Val genotype was seen predominantly among premenopausal women (OR = 2.08; 95% CI = 1.20, 3.59).

CONCLUSIONS: Cruciferous vegetable intake consistent with high isothiocyanate exposure may reduce breast cancer risk. Cruciferous vegetable intake also may ameliorate the effects of the GSTP1 genotype.

Alternate JournalAm. J. Clin. Nutr.
PubMed ID18326615
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