Comparison of islet cell antibodies, islet cell surface antibodies and anti-bovine serum albumin antibodies in type 1 diabetes.

TitleComparison of islet cell antibodies, islet cell surface antibodies and anti-bovine serum albumin antibodies in type 1 diabetes.
Publication TypeJournal Article
Year of Publication1990
AuthorsYokota A, Yamaguchi Y, Ueda Y, Nakanishi T, Ikari N, Akazawa S, Miyake S, Nagataki S
JournalDiabetes research and clinical practice
Volume9
Issue3
Pagination211-7
Date Published1990 Jul
ISSN0168-8227
KeywordsAdolescent, Adult, Antibodies, Autoantibodies, Child, Diabetes Mellitus, Type 1, Female, Humans, Insulinoma, Male, Serum Albumin, Bovine
Abstract

The present study was undertaken to compare the changes in islet cell antibodies (ICA), islet cell surface antibodies using rat insulinoma cells (RINr-ICSA), and anti-bovine serum albumin antibodies (BSA-Ab) in the clinical course of type 1 (insulin-dependent) diabetes. Sera were obtained from 57 patients with type 1 diabetes and 47 normal controls. ICA, RINr-ICSA and BSA-Ab were detected by an enzymatic immunohistochemical method, an indirect immunofluorescence method and an enzyme-linked immunosorbent assay, respectively. The incidence of ICA significantly decreased with the duration of diabetes: less than 1 year: 5/6 (83%); 1-2 years: 3/6 (50%); 2-3 years; 2/6 (33%); greater than 3 years 6/39 (15%). There was a significant positive correlation between RINr-ICSA and BSA-Ab (P less than 0.05). These findings suggest that RINr-ICSA or BSA-Ab may be produced by some similar immune mechanism which is, however, different from ICA, and that they have no direct relation to the clinical course of diabetes.

Alternate JournalDiabetes Res. Clin. Pract.
PubMed ID2226120
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