Childhood energy intake and adult mortality from cancer: the Boyd Orr Cohort Study.

Notes: 

3834 subjects (the Boyd Orr Cohort) tracked for 50 years. Least calories consumed in childhood: dramatic reductions in breast, prostate and colon cancer as adults. Each 238 calorie daily increase in consumption increased cancer mortality as an adult by 20%.

Animal studies have shown that energy restriction results in a reduced risk of cancer. Some cancers are more common in taller people, suggesting that the same effect may be important in humans
+ The association between diet in childhood and later cancer was examined on the basis of detailed dietary data collected from a cohort of children in the late 1930s
+ A positive association emerged between childhood energy intake and later cancer (other than cancer related to smoking), once adjustment for socioeconomic variables had been made
+ This evidence for long term effects of early diet confirms the importance of optimal childhood nutrition by implying that higher levels of energy intake in childhood increase the risk of the later development of cancer.

The effect of childhood energy intake on later mortality from cancer was seen only for cancers not related to smoking.

Children who consumed the highest quartile of fruit during childhood had a 38 percent lower occurrence of all cancers as adults

TitleChildhood energy intake and adult mortality from cancer: the Boyd Orr Cohort Study.
Publication TypeJournal Article
Year of Publication1998
AuthorsFrankel S, Gunnell DJ, Peters TJ, Maynard M, Davey Smith G
JournalBMJ (Clinical research ed.)
Volume316
Issue7130
Pagination499-504
Date Published1998 Feb 14
ISSN0959-8138
KeywordsAdolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Cohort Studies, diet, Energy Intake, England, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Neoplasms, Proportional Hazards Models, Rural Health, Scotland, Selection Bias, Sex Factors, Social Class, Survival Rate, Urban Health
Abstract

OBJECTIVE: To examine the relation between energy intake in childhood and adult mortality from cancer.

STUDY DESIGN: Cohort study.

SETTING: 16 rural and urban centres in England and Scotland.

SUBJECTS: 3834 people who took part in Lord Boyd Orr's Carnegie survey of family diet and health in prewar Britain between 1937 and 1939 who were followed up with the NHS, central register. Standardised methods were used to measure household dietary intake during a one week period.

MAIN OUTCOME MEASURES: Cancer mortality.

RESULTS: Significant associations between childhood energy intake and cancer mortality were seen when the confounding effects of social variables were taken into account in proportional hazards models (relative hazard for all cancer mortality 1.15 (95% confidence interval 1.06 to 1.24), P = 0.001, for every MJ increase in adult equivalent daily intake in fully adjusted models). This effect was essentially limited to cancers not related to smoking (relative hazard 1.20; 1.07 to 1.34; P = 0.001), with similar effects seen in men and women.

CONCLUSION: This positive association between childhood energy intake and later cancer is consistent with animal evidence linking energy restriction with reduced incidence of cancer and the association between height and human cancer, implying that higher levels of energy intake in childhood increase the risk of later development of cancer. This evidence for long term effects of early diet confirm the importance of optimal nutrition in childhood and suggest that the unfavourable trends seen in the incidence of some cancers may have their origins in early life.

Alternate JournalBMJ
PubMed ID9501710
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