Carbohydrates, dietary fiber, and incident type 2 diabetes in older women.


6-year prospective study of 36,000 Iowa women: least diabetes occurred with most whole grain and fiber consumption.

TitleCarbohydrates, dietary fiber, and incident type 2 diabetes in older women.
Publication TypeJournal Article
Year of Publication2000
AuthorsMeyer KA, Kushi LH, Jacobs DR, Slavin J, Sellers TA, Folsom AR
JournalThe American journal of clinical nutrition
Date Published2000 Apr
KeywordsAged, Aging, Blood Glucose, Body Constitution, Body Mass Index, Cereals, Cohort Studies, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Dietary Fiber, Female, Fruit, Humans, Iowa, Magnesium, Middle Aged, Prospective Studies, Risk Factors, Vegetables, Women's Health

BACKGROUND: Dietary carbohydrates may influence the development of type 2 (non-insulin-dependent) diabetes, for example, through effects on blood glucose and insulin concentrations.

OBJECTIVE: We examined the relations of baseline intake of carbohydrates, dietary fiber, dietary magnesium, and carbohydrate-rich foods and the glycemic index with incidence of diabetes.

DESIGN: This was a prospective cohort study of 35988 older Iowa women initially free of diabetes. During 6 y of follow-up, 1141 incident cases of diabetes were reported.

RESULTS: Total grain, whole-grain, total dietary fiber, cereal fiber, and dietary magnesium intakes showed strong inverse associations with incidence of diabetes after adjustment for potential nondietary confounding variables. Multivariate-adjusted relative risks of diabetes were 1.0, 0.99, 0.98, 0.92, and 0.79 (P for trend: 0.0089) across quintiles of whole-grain intake; 1.0, 1.09, 1.00, 0.94, and 0.78 (P for trend: 0.005) across quintiles of total dietary fiber intake; and 1.0, 0.81, 0.82, 0.81, and 0.67 (P for trend: 0.0003) across quintiles of dietary magnesium intake. Intakes of total carbohydrates, refined grains, fruit and vegetables, and soluble fiber and the glycemic index were unrelated to diabetes risk.

CONCLUSION: These data support a protective role for grains (particularly whole grains), cereal fiber, and dietary magnesium in the development of diabetes in older women.

Alternate JournalAm. J. Clin. Nutr.
PubMed ID10731498
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