Bone mineral density and risk of breast cancer: differences by family history of breast cancer. Study of Osteoporotic Fractures Research Group.

TitleBone mineral density and risk of breast cancer: differences by family history of breast cancer. Study of Osteoporotic Fractures Research Group.
Publication TypeJournal Article
Year of Publication1998
AuthorsLucas FL, Cauley JA, Stone RA, Cummings SR, Vogt MT, Weissfeld JL, Kuller LH
JournalAmerican journal of epidemiology
Volume148
Issue1
Pagination22-9
Date Published1998 Jul 1
ISSN0002-9262
KeywordsAged, Aged, 80 and over, Analysis of Variance, Bone Density, Breast Neoplasms, Cohort Studies, Estrogen Replacement Therapy, Female, Humans, Radius, Regression Analysis, Risk Factors
Abstract

Recent studies have suggested that bone mineral density (BMD) is related to risk of breast cancer in elderly women. This study investigated whether the level of breast cancer risk associated with BMD in women with a positive family history of breast cancer is different from that in women without a family history of breast cancer. Radial and calcaneus BMD were measured at baseline (1986-1988) in 7,250 elderly white women enrolled in the Study of Osteoporotic Fractures, and initial breast cancer status was ascertained at year 1 of follow-up. After a mean of 3.2 years of additional follow-up, 104 incident breast cancer cases, 20 of which appeared in women with a family history of breast cancer, were identified and confirmed by medical record review. Modification of the BMD effect by family history status was assessed by inclusion of interaction terms in proportional hazards regression models. Among women without a family history of breast cancer, those with a proximal radius BMD in the highest tertile were at a 1.48-fold increased risk compared with women in the lowest tertile; among women with a positive family history of breast cancer, those with highest tertile BMD were at a 3.41-fold increased risk compared with women in the lowest tertile. These results suggest that the association between BMD and breast cancer may be different in subgroups of women defined by family history.

Alternate JournalAm. J. Epidemiol.
PubMed ID9663400
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