Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease.

Notes: 

n-3 PUFA dietary intake exerts neuroprotective actions in an animal model of Parkinsonism

TitleBeneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease.
Publication TypeJournal Article
Year of Publication2008
AuthorsBousquet M, Saint-Pierre M, Julien C, Salem N, Cicchetti F, Calon F
JournalThe FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume22
Issue4
Pagination1213-25
Date Published2008 Apr
ISSN1530-6860
KeywordsAnimals, Disease Models, Animal, DNA-Binding Proteins, Dopamine, Fatty Acids, Omega-3, Mice, Mice, Inbred C57BL, Models, Biological, MPTP Poisoning, Neuroprotective Agents, Nuclear Receptor Subfamily 4, Group A, Member 2, Prefrontal Cortex, Transcription Factors, Tyrosine 3-Monooxygenase
Abstract

In this study, we examined whether omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may exert neuroprotective action in Parkinson's disease, as previously shown in Alzheimer's disease. We exposed mice to either a control or a high n-3 PUFA diet from 2 to 12 months of age and then treated them with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 140 mg/kg in 5 days). High n-3 PUFA dietary consumption completely prevented the MPTP-induced decrease of tyrosine hydroxylase (TH)-labeled nigral cells (P<0.01 vs. MPTP mice on control diet), Nurr1 mRNA (P<0.01 vs. MPTP mice on control diet), and dopamine transporter mRNA levels (P<0.05 vs. MPTP mice on control diet) in the substantia nigra. Although n-3 PUFA dietary treatment had no effect on striatal dopaminergic terminals, the high n-3 PUFA diet protected against the MPTP-induced decrease in dopamine (P<0.05 vs. MPTP mice on control diet) and its metabolite dihydroxyphenylacetic acid (P<0.05 vs. MPTP mice on control diet) in the striatum. Taken together, these data suggest that a high n-3 PUFA dietary intake exerts neuroprotective actions in an animal model of Parkinsonism.

Alternate JournalFASEB J.
PubMed ID18032633
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