Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.

TitleApolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.
Publication TypeJournal Article
Year of Publication1997
AuthorsSlooter AJ, Tang MX, van Duijn CM, Stern Y, Ott A, Bell K, Breteler MM, Van Broeckhoven C, Tatemichi TK, Tycko B, Hofman A, Mayeux R
JournalJAMA : the journal of the American Medical Association
Volume277
Issue10
Pagination818-21
Date Published1997 Mar 12
ISSN0098-7484
KeywordsAged, Aged, 80 and over, Alleles, Analysis of Variance, Apolipoproteins E, Case-Control Studies, Cerebrovascular Disorders, Dementia, Female, Gene Frequency, Genotype, Humans, Logistic Models, Male, Neuropsychological Tests, Risk Factors
Abstract

OBJECTIVE: To investigate the association between the apolipoprotein E (APOE) genotypes and dementia in patients with stroke, defined as either vascular dementia (VaD) or Alzheimer disease with cerebrovascular disease (AD with CVD).

DESIGN AND SETTING: Population-based, case-control study from Rotterdam, the Netherlands, and New York City.

PARTICIPANTS: A total of 187 patients with dementia and stroke were compared with 507 controls similar in age and ethnic group.

MAIN OUTCOME MEASURES: The APOE allele frequencies in patients and controls; the odds ratio of dementia with stroke, VaD, and AD with CVD, adjusted for age, sex, residency, and education; and the percent attributable risk related to the APOE epsilon4 allele.

RESULTS: Overall, patients with dementia and stroke had a higher APOE epsilon4 allele frequency than controls. Compared with APOE epsilon3 homozygote individuals, APOE epsilon4 homozygotes had a 7-fold increased risk of dementia with stroke (OR=6.9; 95% CI, 1.6-29.4), while APOE epsilon4 heterozygotes had nearly a 2-fold increase in risk (OR=1.8; 95% CI, 1.2-2.7). Risks associated with APOE epsilon4 were elevated regardless of the subtype of dementia with stroke or age or sex. The percent attributable risk related to the APOE epsilon4 allele among demented patients with stroke was 41% overall, 33% among those with VaD, and 44% among those with AD with CVD.

CONCLUSION: The APOE epsilon4 allele is a genetic risk factor for dementia with stroke, including VaD and AD with CVD. This may imply shared genetic susceptibility to dementia associated with stroke and AD. Alternatively, the category of patients with dementia and stroke, including VaD as currently defined, may include patients with AD.

Alternate JournalJAMA
PubMed ID9052712
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