The antioxidant responsive element (ARE) may explain the protective effects of cruciferous vegetables on cancer.

Notes: 

NRF-2 proteins are transcription factors that bind to, and active the ARE segments of genes. (These are cellular segments in DNA that produce protein that sucks free radicals out of tissue, more effectively than antioxidant. NRF-2 becomes activated (a normal function) when we eat green vegetables supplying ITCs. When we don't eat cruciferous greens the most important natural defense systems in the cell does not function.

TitleThe antioxidant responsive element (ARE) may explain the protective effects of cruciferous vegetables on cancer.
Publication TypeJournal Article
Year of Publication2003
AuthorsFinley JW
JournalNutrition reviews
Volume61
Issue7
Pagination250-4
Date Published2003 Jul
ISSN0029-6643
KeywordsAntioxidants, Brassicaceae, DNA-Binding Proteins, Humans, Neoplasms, NF-E2-Related Factor 2, Trans-Activators, Vegetables
Abstract

Research supports the hypothesis that one's diet has a great impact on his or her risk of cancer. Many studies have found that increased fruit and vegetable intake decreases the risk of cancer. Cruciferous vegetables such as broccoli and cauliflower seem to be especially protective against cancer. Most studies show that phytochemicals in crucifers up-regulate many detoxification enzyme systems in the animal that consumes them. Recent reports of the molecular events involved in the activation of a gene promoter called the antioxidant responsive element have begun to provide clues as to how a single substance may induce a battery of many genes.

Alternate JournalNutr. Rev.
PubMed ID12918878
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