1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4.

Title1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4.
Publication TypeJournal Article
Year of Publication1998
AuthorsCantorna MT, Woodward WD, Hayes CE, Deluca HF
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume160
Issue11
Pagination5314-9
Date Published1998 Jun 1
ISSN0022-1767
KeywordsAdjuvants, Immunologic, Administration, Oral, Animals, Calcitriol, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental, Female, Interferon-gamma, Interleukin-4, Lymph Nodes, Lymphocyte Count, Male, Mice, Mice, Inbred C57BL, Spinal Cord, Transcription, Genetic, Transforming Growth Factor beta, Tumor Necrosis Factor-alpha
Abstract

Previously we demonstrated that 1,25-dihydroxyvitamin D3 blocks the progression of relapsing encephalomyelitis. We now propose that 1,25-dihydroxyvitamin D3 blocks these autoimmune symptoms by stimulating the differentiation and/or function of cells that inhibit the encephalitogenic process. To support this belief, we have found that 1,25-dihydroxyvitamin D3 administration to mice increases IL-4 transcripts by 3- to 25-fold and TGF-beta 1 transcripts by 4- to 24-fold. Similarly, IL-4 and TGF-beta 1 transcripts were higher in the central nervous system of 1,25-dihydroxyvitamin D3-treated mice compared with controls. The number of cells recoverable from the lymph nodes of 1,25-dihydroxyvitamin D3-treated mice was only 50% that of controls. Overall, 1,25-dihydroxyvitamin D3 treatment causes a net loss in the total number of lymphocytes while the number of IL-4 and TGF-beta 1 transcripts increased. The systemic and local increase in the expression of these two anti-inflammatory cytokines by 1,25-dihydroxyvitamin D3 may be responsible for the ability of this drug to block encephalomyelitis.

Alternate JournalJ. Immunol.
PubMed ID9605130
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