1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease.

Title1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease.
Publication TypeJournal Article
Year of Publication2000
AuthorsCantorna MT, Munsick C, Bemiss C, Mahon BD
JournalThe Journal of nutrition
Volume130
Issue11
Pagination2648-52
Date Published2000 Nov
ISSN0022-3166
KeywordsAnalysis of Variance, Animals, Body Weight, Calcitriol, Calcium, Disease Models, Animal, Female, Genotype, Inflammatory Bowel Diseases, Interleukin-10, Male, Mice, Mice, Knockout, Vitamin D Deficiency
Abstract

Anecdotal data suggest that the amount of vitamin D available in the environment either from sunshine exposure or diet may be an important factor affecting the development of inflammatory bowel disease (IBD) in humans. We tested the vitamin D hypothesis in an experimental animal model of IBD. Interleukin (IL)-10 knockout (KO) mice, which spontaneously develop symptoms resembling human IBD, were made vitamin D deficient, vitamin D sufficient or supplemented with active vitamin D (1,25-dihydroxycholecalciferol). Vitamin D-deficient IL-10 KO mice rapidly developed diarrhea and a wasting disease, which induced mortality. In contrast, vitamin D-sufficient IL-10 KO mice did not develop diarrhea, waste or die. Supplementation with 50 IU of cholecalciferol (5.0 microgram/d) or 1, 25-dihydroxycholecalciferol (0.005 microgram/d) significantly (P < 0. 05) ameliorated symptoms of IBD in IL-10 KO mice. 1, 25-Dihydroxycholecalciferol treatment (0.2 microgram/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD.

Alternate JournalJ. Nutr.
PubMed ID11053501
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