Ti Sano 2013

Nid Year Notes All terms
83 1 2002

21,454 male participants enrolled in the U.S. Physicians’ Health Study, followed for an average of 17 years. Most dramatic relationship between survival with any food was nut consumption.

Compared with men who rarely or never consumed nuts, those who consumed nuts 2 or more times per week had a 47% lower risk (nearly half the risk) of sudden cardiac death and a 30% lower risk of total coronary heart disease death. (70% of risk for total coronary heart disease).

Nuts and seeds had anti-arrhythmic and anti-seizure effect associated with 60% reduction in sudden cardiac death.

This pattern of benefit on coronary heart disease end points suggests that at least part of the effect of nut consumption on sudden cardiac death may be due to a reduction in fatal ventricular arrhythmias. "consumption of nuts powerfully reduces the chance of having a life-threatening cardiac arrhythmia called ventricular fibrillation or ventricular tachycardia. (People who have heart disease do not always die of heart attacks; they die of an irregular heartbeat that prevents the heart from pumping properly.) Removing nuts and seeds from one’s diet may actually increase the risk of one of these fatal rhythm disturbances."

DPYCCH01, Duplicate, Getaway2010, important, Ti Sano 2013, NET, Disease-Proof Your Child
84 2 1999

frequency of nut consumption has been found to be inversely related to all-cause mortality in several population groups such as whites, blacks, and the elderly. Thus, nut consumption may not only offer protection against IHD, but also increase longevity. In a large, prospective epidemiologic study of Seventh-day Adventists in California, we found that frequency of nut consumption had a substantial and highly significant inverse association with risk of myocardial infarction and death from IHD. The Iowa Women's Health Study also documented an association between nut consumption and decreased risk of IHD.

DPYCCH01, Duplicate, Getaway2010, Ti Sano 2013, Disease-Proof Your Child
302 3 2006

U or J phenomenon of mortality;

pulse pressure increased by medications - normal is 40 or less

reduced diastolic associated with heart attacks.

diastolic below 60 had 3x the heart attack rate and dramatically increases risk of irregular heart beat

beta blockers increase stroke risk and overall mortality

Certificate in Plant-based Nutrition, McDougall Lecture, Getaway2011, important, Ti Sano 2013
565 4 2002

13 countries studied; cancer deaths per 100,000 people; Cancer rates increased

Getaway2011, Ti Sano 2013
575 5 2006

Beta blockers increase glucose intolerance and predispose to and worsen diabetes. Pseudo-anti-hypertensive effects; Systolic (higher number, goes up when heart pumps - we want this to be naturally low) and diastolic blood pressures (lower number, when heart relaxes; blood vessel should come in, making this number higher. but medication lower both systolic and diastolic, promoting irregular heart beat. Widened pulse pressure also predicts a higher risk of subsequent cardiovascular events, stroke, renal disease, heart failure, and mortality, particularly in the elderly.

CVD, Getaway2011, Ti Sano 2013
578 6 2009

Men consuming 7 or more eggs per week are 58% more likely to develop type-2 diabetes and women are 77% more likely. Men with diabetes who ate any eggs at all were twice as likely to die in the 20 year period. The researchers are not sure which component of the egg is to blame; however suggestive evidence was present for increased risk of heart attack and stroke.

Diabetes, Getaway2010, Getaway2011, Ti Sano 2013
584 7 2000

Fish Oil (EPA), Vitamin D, food allergy elimination diets

Getaway2011, Ti Sano 2013
592 8 2010

Over 1000 people tracked; 5 or more days/ week: 46% fewer infections; milder infections when sick; 41 percent less sick days.

Getaway2011, Ti Sano 2013
593 9 2005

IGF-1 increases in response to exercise; does not raise circulation or systemic IGF-1 (unless animal protein is consumed)

Getaway2011, Ti Sano 2013
594 10 1995

Prospective cohort study. Over 17,000 men followed for 26 years. Those that exercised vigorous lived the longest. Walks not good enough. Jump, and hang. Hang upside down; Exercise intensity matters

Fall Weekend Immersion 2011, Getaway2011, Ti Sano 2013
595 11 1994
Baron S, Rinsky R. NIOSH mortality study of NFL football players: 1959-1988. Cincinnati, OH: Centers for Disease Control, National Institute for Occupational Safety and Health. 1994:88-085.

Mortality study of 6,848 professional football players. Large football players -> twice the risk of early cardiac death (half dead before age 50.) 10 of 600 athletes on the 1964 East German Olympic Team is alive today. Players with largest BMI (muscle) had 6x the early death compared with those with the lowest BMI.

Fall Weekend Immersion 2011, Getaway2010, Getaway2011, Ti Sano 2013
596 12 2004

7 - 8% reduction in mortality for every 20 gram increase in daily legume intake. (20 gms is about 3/4 of an ounce)

Fall Weekend Immersion 2011, Getaway2011, Ti Sano 2013, NET
601 13 2009

Intake of mushrooms decreased the risk of breast cancer by 64%. Mushrooms are aromatase inhibitors, which detoxify estrogens.

Getaway2010, Getaway2011, Getaway2012, Ti Sano 2013, VegSource Healthy Lifestyle Expo 2009
603 14 2006

Reductions among highest consumers of onions:
Colon cancer: 56%
Ovarian cancer: 73%
Esophogeal Cancer: 88%
Prostate Cancer: 71%
Stomach Cancer: 50%
Pharynx and Oral cancer: 84%

Getaway2011, Ti Sano 2013
605 15 2006

71 countries studied
Increase Risk: Animal food, animal fat, milk, sugar, alcohol, stimulants;
Decrease Risk: sunshine, onions, soybeans, beans, (green veggies)

DPYCCH01, Getaway2010, Getaway2011, Getaway2012, Ti Sano 2013, Disease-Proof Your Child
607 16 2008

Will men adhere to tomato intervention? Prostate cancer patients will consume diets rich in tomato products and soy with excellent compliance and bioavailability of phytochemicals.

Cancer, Getaway2010, Getaway2011, Getaway2012, Ti Sano 2013
673 17 2009

Greens needed to activate NRF2 proteins (transcription factors), which prevents plaque adhesion--makes slippery. highest level of blood lutein have healthiest blood vessels with no atherosclerosis; (lutein level mostly a research tool.)

CVD, Getaway2010, Getaway2011, important, Ti Sano 2013
689 18 2004

Regardless of ethnic group or energy adjustment, high and frequent vegetable consumption (particularly dark green vegetables) was protective, consistent with 20-50% reductions in risk. In Caucasians, high refined carbohydrate and red meat consumption (amount and frequency) was associated with a statistically significant 2-fold increased risk in non-energy adjusted models. In African-Americans, frequent intake of dairy foods was associated with a doubling in risk (OR = 1.9, 95% CI = 1.1-3.4) in non-energy-adjusted models, whereas frequent fruit consumption correlated with a non-significant 30% lower risk.

DPYCCH03, Getaway2010, Ti Sano 2013, Disease-Proof Your Child
699 19 2003

NRF-2 proteins are transcription factors that bind to, and active the ARE segments of genes. (These are cellular segments in DNA that produce protein that sucks free radicals out of tissue, more effectively than antioxidant. NRF-2 becomes activated (a normal function) when we eat green vegetables supplying ITCs. When we don't eat cruciferous greens the most important natural defense systems in the cell does not function.

Cancer, Getaway2011, Ti Sano 2013, NET
710 20 2005

Review of 23 interventional trials show dramatic reduction in all-cause mortality by those consuming nuts and seeds

Consumption of approximately 50-100 g (approximately 1.5-3.5 servings) of nuts 5 or more times/wk as part of a heart-healthy diet with total fat content (high in mono- and/or polyunsaturated fatty acids) of approximately 35% of Energy may significantly decrease total cholesterol and LDL cholesterol (especially small dense LDL) in normo- and hyperlipidemic individuals.

Sudden Cardiac Death (the most common cause of death in people with no known heart disease) constitutes almost 40 percent of all heart disease deaths

The most proven and effective intervention to reducing risk of sudden cardiac death is the regular consumption of seeds and nuts in the diet.

the magnitude of the cholesterol-lowering effect was shown to be 25% greater than would be predicted based on the fatty acid profiles of the test diets studied (2). Therefore, the possible mechanisms whereby nuts may improve lipid profiles do not rely exclusively on the beneficial action of unsaturated fatty acids (PUFA and MUFA) but may include the effects of fiber, micronutrients such as vitamin E and C, folic acid, copper, magnesium, plant protein (e.g., arginine), plant sterols, and phenolic components.

"Large drop in LDL cholesterol, especially the most dangerous small LDL. Raise LDL. Reduce CRP and plaque adhesion molecules. Increase arginine. Restore vascular elasticity."

- increase arginine
- restore vascular elasticity
- recue c-reactive protein and plaque adhesion
- raise hdl
- large drop in ldl especially most dangerous type

Getaway2010, Ti Sano 2013
881 21 2010

White rice increased breast cancer risk (19% increase in risk per 100 g per day); wild brown/black rice decreased risk (24% decrease per 100g per day

Getaway2011, Ti Sano 2013
1408 22 2011

(aryl hydrocarbon receptor intestinal lymphocytes)

Getaway2012, Ti Sano 2013
1409 23 2004

JAMA:
26+ prescriptions: 2x risk of breast cancer. (25)
1-25 prescriptions: 1.5 x risk of breast cancer (2 - 25)
True across all classes of antibiotics

Cancer, Ti Sano 2013, Super Immunity
1423 24 2008

ACCORD (Action to Control Cardiovascular Risk in Diabetes)
study was halted. As compared with standard therapy, the use of intensive therapy to target normal glycated hemoglobin levels for 3.5 years increased mortality and did not significantly reduce major cardiovascular events.

Diabetes, Super Immunity Ch 2, Ti Sano 2013, Super Immunity
1487 25 2008

Increased risk of dying, the more medical care

Diabetes, Ti Sano 2013
1555 26 2012

from: http://www.rheumatologynews.com/news/clinical-news/single-article/hip-fr...

Hypertensive elderly persons who began receiving an antihypertensive drug had a 43% increased risk of having a hip fracture during the first 45 days following treatment initiation relative to the control periodsThe risk of early fracture rose by 53% for patients started on an ACE inhibitor and by 58% for those on beta-blockers

Ti Sano 2013
1556 27 2003
Ti Sano 2013
1581 28 2010

Total meat consumption was positively associated with weight gain in men and women, in normal-weight and overweight subjects, and in smokers and nonsmokers. With adjustment for estimated energy intake, an increase in meat intake of 250 g/d (eg, one steak at approximately 450 kcal) would lead to a 2-kg (4.4 pound) higher weight gain after 5 years. Positive associations were observed for red meat, poultry, and processed meat.

CONCLUSION: Our results suggest that a decrease in meat consumption may improve weight management.

Ti Sano 2013